Dietary Antioxidants Protect Hematopoietic Cells and Improve Animal Survival after Total-Body Irradiation
نویسندگان
چکیده
منابع مشابه
Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival.
Abstract Dietary antioxidants have radioprotective effects after gamma-radiation exposure that limit hematopoietic cell depletion and improve animal survival. The purpose of this study was to determine whether a dietary supplement consisting of l-selenomethionine, vitamin C, vitamin E succinate, alpha-lipoic acid and N-acetyl cysteine could improve survival of mice after proton total-body irrad...
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Background: The hematopoietic system is sensitive to the adverse effects of ionizing radiation. Cellular therapies utilizing mesenchymal stem cells or vascular endothelial cells have been explored as potential countermeasures for radiation hematopoietic injuries. We investigated cells cultured from amnion ...
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BACKGROUND The potential of ascorbic acid and two botanical decoctions, green tea and cat's claw, to limit cell death in response to oxidants were evaluated in vitro. METHODS Cultured human gastric epithelial cells (AGS) or murine small intestinal epithelial cells (IEC-18) were exposed to oxidants - DPPH (3 microM), H2O2 (50 microM), peroxynitrite (300 microM) - followed by incubation for 24 ...
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criteria and 40% in the best schedule (5-day intravenous). This compares favorably with prior experiences with decitabine and 5-azacitidine (CR rates, 6%-20%).4,5 Also, decitabine was less toxic than 5-azacitidine in relation to nausea/vomiting and local skin reactions (pain and induration in 5%-10% of patients on 5-azacitidine). The incidence of 65% of hospitalization is cumulative. As one del...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 2008
ISSN: 0033-7587,1938-5404
DOI: 10.1667/rr1204.1